0.5 fl oz / 15 ml - Item# 3356

$50.00 USD product review stars (0 reviews)

SeneDerm Solutions Spot-On Blemish & Acne Treatment

Use this targeted acne treatment to help skin become clearer and smoother, reduce redness and inflammation, while helping to fight signs of aging.

  • Contains Benzoyl Peroxide to effectively kill bacteria and treat acne
  • Includes key vitamins to revitalize skin and anti-aging ingredients to increase cellular renewal
  • Feels cooling and soothing with aloe vera


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The effective solution to help reduce the appearance of blemish and acne spots on skin. Formulated with a powerful anti-acne agent, this targeted “spot remover” works directly on unsightly blemishes to clear them up quick.

The Science Behind the Product 

Active Ingredient: Benzoyl Peroxide (BPO)  9.48%. This hardworking pimple fighter has been proven effective in treating acne by killing the Propionibacteria acnes bacteria responsible for outbreaks. However, irritation is a common problem when BPO is not dissolved or delivered effectively. 

In response to this problem Dimethyl Isosorbide (DMI) was designed to help dissolve actives such as BPO in formulations and prevent its re-agglomeration (act or process of gathering into a mass). This increases the efficacy of BPO by limiting its particle size to better target the pores and eliminate the source of acne. Further, by keeping the particles from re-agglomerating, it reduces skin irritation. It is generally known that actives are only as effective as the vehicles used to deliver them. DMI is designed to aid penetration into the epidermis by increasing the polarity of the surface skin layers to carry the active BPO to the pores of the skin in order to kill the bacteria that cause acne, where it can act more effectively. 

In fact, the ingredient was shown to be a better delivery vehicle for BPO than Ethoxydiglycol (EDG) a commonly used competitive material, as determined experimentally and in a theoretical model comparing the polarity of the delivery vehicle to the solute, in this case BPO. 

It was found that more than double the amount of BPO can be dissolved in Dimethyl Isosorbide than in such competitive delivery vehicles. In addition, Dimethyl Isosorbide ensures BPO has maximum contact time with the pores and acne-causing bacteria. However, it was not shown to promote penetration into the bloodstream. DMI, a methylated sorbitol derivative, enhances the activity of BPO while reducing its skin irritation potential. This material increases the effectiveness of actives in formulations. 

Key Ingredients and Benefits 

Octiperox – an anti-bacterial and anti-fungal

Allantoin – an anti-irritant

Panthenol (pro Vitamin B) - Besides the wrinkle reducing effects that panthenol provides to skin, it has been proven in numerous studies that panthenol can be used for acne treatment and acne prevention.

Aloe Vera- helpful in treating skin diseases and helps in healing wounds.

Coolant 10 – a cooling agent

Active Ingredient Purpose Benzoyl Peroxide 9.48% 

Inactive Ingredients: Allantoin, Aloe Barbadensis (Aloe Vera) Leaf Juice, Bisabolol, C13-14 Isoparaffin, Caprylyl Glycol, Dimethyl Isosorbide, Ethylhexylglycerin, Hexylene Glycol, Laureth-7, Menthoxypropanediol, Panthenol, Phenoxyethanol, Piroctone Olamine, Polyacrylamide, Water (Aqua), Zingiber Officinale (Ginger) Root Extract.

Apply to thoroughly cleansed, affected areas of skin before moisturizing day and night or as needed to help eliminate blemish and acne spots of skin. If excessive drying and peeling occurs, start with one application, gradually increase to twice daily, or as directed by a doctor. For external use only. Do not use in combination with additional topical acne medications, other than the SeneDerm Oily to Acne product line system.